Summary. Background: Multiple platelet function tests claim to be P2Y12‐pathway specific and capable of capturing the biological activity of clopidogrel. Platelets (thrombocytes) are cell fragments vital for normal blood clotting. Platelet function tests (e.g., aggregation, flow cytometry) help diagnose platelet disorders or aspirin resistance or monitor anti-platelet therapy (e.g., clopidogrel). Actually you can reduce cholesterol produce. It can be created when incorporated in the liver which supply of two broad types are needed just for ANA; positive b negative a normally low levels. This test has also been named P2Y12 Response Assay to avoid confusion with other tests such as the platelet function assay (PFA-100) and platelet aggregation. Also, the use of this test is not limited to clopidogrel. It can be used to measure the effect of other P2Y12 drugs, such as prasugrel and ticagrelor. This rapid and comprehensive platelet function test involves adding platelet agonists manually and is prognostically useful in clopidogrel-treated patients undergoing PCI. However, evidence is lacking that shows it improves clinical outcomes when used for guiding therapy (1). This test may be abnormal if the platelet count is low, if platelet function is reduced, if other proteins needed for platelet function are reduced, or if anti-platelet medications are present. This type of assay can be used to screen for von Willebrand disease and some platelet function disorders, but it will not detect all platelet function disorders, particularly the milder forms. Key words: antiplatelet therapy, high platelet reactivity (HPR), antiplatelet drug resistance, platelet function test, drug monitoring INTRODUCTION Platelets are an essential component of blood coagulation and are responsible for maintaining primary hemostasis under conditions of blood flow. Key words: antiplatelet therapy, high platelet reactivity (HPR), antiplatelet drug resistance, platelet function test, drug monitoring. A BSTRACT Cardiovascular diseases are the leading cause of death in the Western world. All patients received a baseline P2Y12 platelet function test to identify clopidogrel resistance and determine whether they would need another loading dose to achieve P2Y12 response around 20% before the NV procedure. Platelet function tests for monitoring antiplatelet agent therapy Point-of-care Arizona February 21, 2017 Brad S. Karon MD PhD Associate Professor of Laboratory Medicine and Pathology Co-director, Point of Care Testing Mayo Clinic Rochester. Learning objectives • Describe the principles of different tests used to monitor platelet function • Define limitations in assessing response to.